Felodipine

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Chemical Information

Product name：Felodipine	Purity：99% min
CAS NO：72509-76-3	Solubility：DMSO : 100 mg/mL (260.25 mM)
Molecular Formula：C₁₈H₁₉Cl₂NO₄	Package：Package according to customer requirements
Molecular Weight：384.254	Storage：Store at -20℃

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Remarks

Felodipine is a calcium channel blocker (calcium antagonist), used to control hypertension. Felodipine prevents calcium from being released within the muscle cells of the small arteries and thereby causes the muscles to relax and the arteries to dilate or expand. Dilation of arteries reduces blood pressure. Felodipine has little or no effect on the muscles of veins or the heart.

Properties:

Appearance & Physical State: White or light yellow crystalline powder
Density: 1.277 g/cm3
Melting Point: 142-145ºC
Boiling Point: 471.5ºCat 760 mmHg
Flash Point: 239ºC
Refractive Index: 1.549

Calcium Channel Inhibitors Related Products:

Manidipine 2HCl; Nisoldipine; Fasudil HCl; Cilnidipine; Dronedarone HCl; Clevidipine Butyrate; Efonidipine; Amlodipine; ISX-9 (Isoxazole 9); Gabapentin; MRS 1845; Fantofarone; Suvecaltamide (MK-8998); Ziconotide; Catharanthine Tartrate; Bepridil hydrochloride

References

[1]. Johnson, J.D. and D.A. Fugman, Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther, 1983. 226(2): p. 330-4.

[2]. Rodler, S., et al., Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells. J Mol Cell Cardiol, 1995. 27(10): p. 2295-302.