Manidipine, also known as CV-4093, is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. In addition, manidipine does not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation. Manidipine has shown antihypertensive efficacy and appears to be well tolerated in adult and elderly patients with mild or moderate essential hypertension.
Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.
Calcium Channel Inhibitors Related Products:
Manidipine 2HCl; Felodipine; Nisoldipine; Fasudil HCl; Cilnidipine; Dronedarone HCl; Clevidipine Butyrate; Efonidipine; Amlodipine; ISX-9 (Isoxazole 9); Gabapentin; MRS 1845; Fantofarone; Suvecaltamide (MK-8998); Ziconotide; Catharanthine Tartrate; Bepridil hydrochloride