VTP-27999 TFA

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Chemical Information

Product name：VTP-27999 TFA	Purity：99.0% min
CAS NO：1013937-63-7	Solubility：Ethanol : 2.4 mg/mL (3.76 mM; Need ultrasonic)
Molecular Formula：C₂₈H₄₂ClF₃N₄O₇	Package：Package according to customer requirements
Molecular Weight：639.104	Storage：Store at -20℃

Quality control

Remarks

VTP-27999 TFA (VTP-27999 Trifluoroacetate, VTP-27999 2,2,2-trifluoroacetate) is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.

RAAS Inhibitors Related Prodcuts:

Aliskiren hemifumarate; Candesartan; Candesartan Cilexetil; Losartan potassium; Enalaprilat dihydrate; Irbesartan; PD123319; Perindopril Erbumine; Ramipril; Captopril; Azilsartan; Eprosartan Mesylate; Azilsartan; Telmisartan; Valsartan; Enalapril Maleate ; Benazepril

References

[1]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.

[2]. Lanqi Jia? et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751