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Candesartan

Candesartan 139481-59-7
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Chemical Information
Product name:Candesartan Purity:98% min
CAS NO:139481-59-7 Solubility:10 mM in DMSO
Molecular Formula:C24H20N6O3 Package:Package according to customer requirements
Molecular Weight:440.454 Storage:Store at -20℃
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Remarks
Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan is marketed as the cyclohexyl 1-hydroxyethyl carbonate (cilexetil) ester, known as candesartan cilexetil. Candesartan cilexetil is metabolised completely by esterases in the intestinal wall during absorption to the active candesartan moieity. The use of a prodrug form increases the bioavailability of candesartan. Despite this, absolute bioavailability is relatively poor at 15% (candesartan cilexetil tablets) to 40% (candesartan cilexetil solution). Its IC50 is 15 µg/kg.
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