PD123319

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Chemical Information

Product name：PD123319	Purity：98% min
CAS NO：130663-39-7	Solubility：Soluble in DMSO
Molecular Formula：C₃₁H₃₂N₄O₃	Package：Package according to customer requirements
Molecular Weight：508.611	Storage：Store at 2-8ºC

Quality control

Remarks

PD-123319 is a selective, nonpeptide AT2R antagonist (IC50 = 5.6 nM vs. 100 nM for AT1R). PD-123319 has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.

Properties:
Density: 1.22 g/cm3
Boiling Point: 775.8ºC at 760 mmHg
Flash Point: 423ºC
Storage Condition: 2-8ºC
Vapor Pressure: 2.48E-25mmHg at 25°C

RAAS Inhibitors Related Prodcuts:

Aliskiren hemifumarate; Candesartan; Candesartan Cilexetil; Losartan potassium; Enalaprilat dihydrate; Irbesartan; Perindopril Erbumine; Ramipril; Captopril; Azilsartan; VTP-27999 TFA; Eprosartan Mesylate; Telmisartan; Valsartan; Enalapril Maleate ; Benazepril

References

[1]. Blankley CJ, et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991 Nov;34(11):3248-60.

[2]. Boulay G, et al. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol Pharmacol. 1992 Apr;41(4):809-15

[3]. Estrup TM, et al. No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation. J Renin Angiotensin Aldosterone Syst. 2001 Sep;2(3):188-92.