Irbesartan, also known as BMS-186295, is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. It selectively and competitively blocks the binding of angiotensin II to the angiotensin I receptor. Angiotensin II stimulates aldosterone synthesis and secretion by adrenal cortex, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle.
Properties:
Appearance & Physical State: white crystalline powder
Density: 1.3 g/cm3
Boiling Point: 648.6ºC at 760 mmHg
Melting Point: 180-181ºC
Flash Point: 346ºC
Refractive Index: 1.689
Storage Condition: Store in original container in a cool dark place.
Vapor Pressure: 1.05E-16mmHg at 25°C
RAAS Inhibitors Related Prodcuts:
Aliskiren hemifumarate; Candesartan; Candesartan Cilexetil; Losartan potassium; Enalaprilat dihydrate; PD123319; Perindopril Erbumine; Ramipril; Captopril; Azilsartan; VTP-27999 TFA; Eprosartan Mesylate; Telmisartan; Valsartan; Enalapril Maleate; Benazepril