Losartan Potassium is a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.
Properties:
Appearance & Physical State: white to off-white crystalline powder
Density: 0.986 g/mL at 25 °C(lit.)
Boiling Point: 682ºC at 760mmHg
Melting Point: 183.5-184.5ºC /Losartan/
Flash Point: 366.3ºC
Refractive Index: n20/D 1.387(lit.)
Vapor Pressure: 1.55E-19mmHg at 25°C
RAAS Inhibitors Related Prodcuts:
Aliskiren hemifumarate; Candesartan; Candesartan Cilexetil; Enalaprilat dihydrate; Irbesartan; PD123319; Perindopril Erbumine; Ramipril; Captopril; Azilsartan; VTP-27999 TFA; Eprosartan Mesylate; Telmisartan; Valsartan; Enalapril Maleate; Benazepril