HOE-498 Ramipril

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Chemical Information

Product name：HOE-498 Ramipril	Purity：98%min
CAS NO：87333-19-5	Solubility：DMSO : ≥ 100 mg/mL (240.09 mM)
Molecular Formula：C₂₃H₃₂N₂O₅	Package：Package according to customer requirements
Molecular Weight：416.511	Storage：Store at 2-8ºC

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Remarks

Ramipril is an inhibitor of the angiotensin- converting enzyme that is reported to quickly hydrolyze into the active metabolite Ramiprilat. Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes.1 Ramipril is a second generation ACE inhibitor that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat.

Properties:

Appearance & Physical State: White solid
Density: 1.2 g/cm3
Melting Point: 106-108ºC
Boiling Point: 616.2ºC at 760 mmHg

RAAS Inhibitors Related Prodcuts:

Aliskiren hemifumarate; Candesartan; Candesartan Cilexetil; Losartan potassium; Enalaprilat dihydrate; Irbesartan; PD123319; Perindopril Erbumine; Ramipril; Captopril; Azilsartan; VTP-27999 TFA; Eprosartan Mesylate; Telmisartan; Valsartan; Enalapril Maleate ; Benazepril

References

[1]. Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22(3): p. 611-8.

[2]. Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91(2): p. 493-7.