Amphotericin B

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Chemical Information

Product name：Amphotericin B	Purity：98% min
CAS NO：1397-89-3	Solubility：DMSO : ≥ 100 mg/mL (108.22 mM); H2O: < 0.1 mg/mL
Molecular Formula：C₄₇H₇₃NO₁₇	Package：Package according to customer requirements
Molecular Weight：924.079	Storage：Store at -20℃

Quality control

COA

Remarks

Amphotericin B binds ergosterol and induces membrane pore formations, increasing ROS and suppressing fungal growth. It also increases expression of IL-1-beta, TNF-alpha, BDNF and GDNF and protects against prion-induced neurodegeneration.

Properties:

Appearance & Physical State: Crystalline Yellow Solid

Density: 1.34

Boiling Point: ,1140.4ºC at 760 mmHg

Melting Point: >170ºC

Flash Point: 643.5ºC

Refractive Index: 1.614

Vapor Pressure: 0mmHg at 25°C

Antibiotics chemical Related Products:

Doripenem Hydrate; Meropenem; Linezolid; Cefoselis Sulfate; Tebipenem; Tebipenem pivoxil; Aztreonam; Cefaclor; Tobramycin; Roxithromycin; Enrofloxacin; Nadifloxacin; Gamithromycin; Orbifloxacin; Polymyxin B Sulfate; Kanamycin; Tildipirosin; Ertapenem Sodium; Faropenem sodium ; Ceftizoxime

References

[1]. Sau K, et al. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem. 2003 Sep 26;278(39):37561-8. Epub 2003 Jul 14.

[2]. Barwicz J, et al. The effect of aggregation state of amphotericin-B on its interactions with cholesterol- or ergosterol-containing phosphatidylcholine monolayers. Chem Phys Lipids. 1997 Feb 28;85(2):145-55.

[3]. Ramos H, et al. Amphotericin B kills unicellular leishmanias by forming aqueous pores permeable to small cations and anions. J Membr Biol. 1996 Jul;152(1):65-75.