Aztreonam is a monobactam antibiotic used primarily to treat infections caused by gram-negative bacteria. Aztreonam is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.
Properties:
Appearance & Physical State: white to off-white crystals
Density: 1.83g/cm3
Melting Point: 227ºC
Refractive Index: 1.74
Antibiotics chemical Related Products:
Doripenem Hydrate; Meropenem; Linezolid; Cefoselis Sulfate; Tebipenem; Tebipenem pivoxil; Amphotericin B; Cefaclor; Tobramycin; Roxithromycin; Enrofloxacin; Nadifloxacin; Gamithromycin; Orbifloxacin; Polymyxin B Sulfate; Kanamycin; Tildipirosin; Ertapenem Sodium; Faropenem sodium; Ceftizoxime