Tebipenem pivoxil

Tebipenem pivoxil, also known as ME1211; SPR994 and TBM-PI, is a novel oral carbapenem antibiotic. TBM-PI is a promising antibiotic for the treatment of acute otitis media. Tebipenem pivoxil displays an excellent antibacterial activity against a variety of pathogenic bacteria in vitro. Importantly, tebipenem pivoxil significantly protects the sepsis mice challenged with various pathogenic bacteria, which may provide a potential approach to treating bacterial sepsis in clinic.

Synonyms:

1'-Hydroxy-1,3-dihydro-6-methoxy-3-phenylspiro(isobenzofuran-1,4'-piperidine);

6-Methoxy-3-phenylspiro(isobenzofuran-1(3H),4'-piperidin)-1'-ol;

Spiro(isobenzofuran-1(3H),4'-piperidin)-1'-ol,6-methoxy-3-phenyl;

1'-hydroxy-5-methoxy-1-phenylspiro[1H-2-benzofuran-3,4'-piperidine]

Properties:

Density: 1.27g/cm3

Boiling Point: 505.6ºC at 760 mmHg

Flash Point: 259.5ºC

Refractive Index: 1.648

Antibiotics chemical Related Products:

Doripenem Hydrate; Meropenem; Linezolid; Cefoselis Sulfate; Tebipenem; Amphotericin B; Aztreonam; Cefaclor; Tobramycin; Roxithromycin; Enrofloxacin; Nadifloxacin; Gamithromycin; Orbifloxacin; Polymyxin B Sulfate; Kanamycin; Tildipirosin; Ertapenem Sodium; Faropenem sodium; Ceftizoxime

[1]. El-Gamal, M.I. and C.H. Oh, Current status of carbapenem antibiotics. Curr Top Med Chem, 2010. 10(18): p. 1882-97.

[2]. Fujimoto, K., et al., Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals. Antimicrob Agents Chemother, 2013. 57(2): p. 697-707.