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1A-116 1430208-73-3
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Chemical Information
Product name:1A-116 Purity:98% min
CAS NO:1430208-73-3 Solubility:Soluble in DMSO
Molecular Formula:C16H16F3N3 Package:Package according to customer requirements
Molecular Weight:307.32 Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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1A-116 is a specific Rac1 inhibitor.


1A-116 shows lesser effect on MCF7::pcDNA.3 cells than on MCF7::C1199 cells. 1A-116 treatment decreases phospho-PAK1 levels in a time-dependent manner. The presence of 1A-116 reverts the PAK1 phosphorylation induced by 4-hydroxytamoxifen (Tam). The presence of 1A-116 also effectively reverts Rac1-PAK1-mediated estrogen receptor (ER) phosphorylation at Ser305[1]. 1A-116 shows a significant increase in antiproliferative activity on F3II cells, showing an IC50 value of 4 µM. A-116 also dramatically impairs Rac1 activation at low micromolar range (1 µM)[2].

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