CID-1067700 is a pan GTPase inhibitor, and competitively inhibits Rab7 with a Ki of 13 nM. CID-1067700 shows inhibitory activity against nucleotide binding by Rab7, with Kds of 100 nM and 40 nM for BODIPY-GTP and BODIPY-GDP, respectively. With increasing concentration, CID-1067700 causes strong inhibition on binding of the BODIPY-linked nucleotides, with EC50 values of 11.22 ± 1.34 nM for BODIPY-GTP and 20.96 ± 1.34 nM for BODIPY-GDP and calculated Ki values of 12.89 nM and 19.70 nM respectively. CID-1067700 (10 μM) has no effect on the rate of release of bound BODIPY-linked nucleotide by wild type Rab7 under equilibrium binding conditions. CID-1067700 (0-40 μM) inhibits Rab7 activity, NF-κB activation as well as AID induction in B cells. Furthermore, CID-1067700 binds Rab7 with a high affinity (EC50: 10-20 nM), and blocks Class switch DNA recombination (CSR) in B cells via targeting Rab7.
Properties:
density:1.410±0.06 g/cm3(Predicted)
form: powder
pka: 4.25±0.40(Predicted)
color: white to light brown
Ras Related Products:
Sotorasib; Ketoconazole; (Rac)-Antineoplaston A10; Kobe0065; Kobe-2602; ML141; Zoledronic acid; Lonafarnib; Adagrasib; Deltarasin; Salirasib; EHop-016; CCG-1423; ZCL-278; 6H05; 1A-116