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CCG-1423 285986-88-1
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Chemical Information
Product name:CCG-1423 Purity:98% min
CAS NO:285986-88-1 Solubility:DMSO : ≥ 26 mg/mL (57.17 mM)
Molecular Formula:C18H13ClF6N2O3 Package:Package according to customer requirements
Molecular Weight:454.751 Storage:Store at -20℃
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CCG-1423 is a small-molecule inhibitor of RhoA transcriptional signaling. CCG-1423 displays activity in several in vitro cancer cell functional assays. CCG-1423 potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, and whereas it inhibits the growth of RhoC-overexpressing melanoma lines (A375M2 and SK-Mel-147) at nanomolar concentrations, it is less active on related lines (A375 and SK-Mel-28) that express lower levels of Rho.
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