CCG-1423

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Chemical Information

Product name：CCG-1423	Purity：98% min
CAS NO：285986-88-1	Solubility：DMSO : ≥ 26 mg/mL (57.17 mM)
Molecular Formula：C₁₈H₁₃ClF₆N₂O₃	Package：Package according to customer requirements
Molecular Weight：454.751	Storage：Store at -20℃

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Remarks

CCG-1423 is a small-molecule inhibitor of RhoA transcriptional signaling. CCG-1423 displays activity in several in vitro cancer cell functional assays. CCG-1423 potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, and whereas it inhibits the growth of RhoC-overexpressing melanoma lines (A375M2 and SK-Mel-147) at nanomolar concentrations, it is less active on related lines (A375 and SK-Mel-28) that express lower levels of Rho.

Ras Related Products:

Sotorasib; Ketoconazole; (Rac)-Antineoplaston A10; CID-1067700; Kobe0065; Kobe-2602; ML141; Zoledronic acid; Lonafarnib; Adagrasib; Deltarasin; Salirasib; EHop-016; ZCL-278; 6H05 ; 1A-116

References

[1]. Evelyn CR, et al. Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72.

[2]. Jin W, et al. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar;121(3):918-29.