K-Ras inhibitor 6H05

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Chemical Information

Product name：K-Ras inhibitor 6H05	Purity：99% min
CAS NO：1469338-01-9	Solubility：DMSO: 100 mg/mL (169.45 mM)
Molecular Formula：C₂₀H₃₀ClN₃O₂S₃.CF₃COOH	Package：Package according to customer requirements
Molecular Weight：590.13	Storage：Store at -20℃

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Remarks

6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).

Synonyms:

1-[2-[(4-Chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide;

4-Piperidinecarboxamide, 1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-;

Properties:

Boiling point: 669.3±55.0 °C(Predicted)

density: 1.29±0.1 g/cm3(Predicted)

pka: 15.05±0.20(Predicted)

Ras Related Products:

Sotorasib; Ketoconazole; (Rac)-Antineoplaston A10; CID-1067700; Kobe0065; Kobe-2602; ML141; Zoledronic acid; Lonafarnib; Adagrasib; Deltarasin; Salirasib; EHop-016; CCG-1423; ZCL-278 ; 1A-116

References

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.

[2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.