ML141

ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.

Synonyms:

4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide;

4-[3-(4-Methoxyphenyl)-1-propyl]piperidine;

Piperidine,4-[3-(4-methoxyphenyl)propyl];

4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide;

Properties:

Melting point: 216 °C(Solv: ethanol (64-17-5))

Boiling point: 622.9±65.0 °C(Predicted)

density: 1.31±0.1 g/cm3(Predicted)

pka: 10.39±0.10(Predicted)

form: Yellow-white solid

color: white to beige

Ras Related Products:

Sotorasib; Ketoconazole; (Rac)-Antineoplaston A10; CID-1067700; Kobe0065; Kobe-2602; Zoledronic acid; Lonafarnib; Adagrasib; Deltarasin; Salirasib; EHop-016; CCG-1423; ZCL-278; 6H05; 1A-116

[1]. Surviladze Z, et al. A Potent and Selective Inhibitor of Cdc42 GTPase. Probe Reports from the NIH Molecular Libraries Program

[2]. Chen HY, et al. Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells. EMBO Mol Med. 2013 May;5(5):723-36.

[3]. Hanin G, et al. Competing targets of microRNA-608 affect anxiety and hypertension. Hum Mol Genet. 2014 Sep 1;23(17):4569-80.