Epothilone A

Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM.

The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.

Properties:
Density: 1.143g/cm3
Melting Point: 95ºC
Boiling Point: 683.3ºC at 760 mmHg
Flash Point: 367.1ºC
Refractive Index: 1.531
Vapor Pressure: 1.31E-19mmHg at 25°C

Microtubule Associated Inhibitors Related Products:

Paclitaxel; Vincristine; Vincristine sulfate; Fosbretabulin disodium; CW069; CK-636; Docetaxel; Docetaxel trihydrate; ABT-751; Nocodazole; Cabazitaxel; Albendazole; Mertansine; SSE15206; ELR510444; Vinorelbine Tartrate; Triclabendazole; Epothilone B

[1]. Kowalski RJ, et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem. 1997 Jan 24;272(4):2534-41.

[2]. Cheng KL, et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2(4):789-811.