CK-636 is a Arp2/3 complex inhibitor. CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movements. CK-636 may be a powerful tool compound for studying the Arp2/3 complex in living cells.
Microtubule Associated Inhibitors Related Products:
Paclitaxel; Vincristine; Vincristine sulfate; Epothilone A; Fosbretabulin disodium; CW069; Docetaxel; Docetaxel trihydrate; ABT-751; Nocodazole; Cabazitaxel; Albendazole; Mertansine; SSE15206; ELR510444; Vinorelbine Tartrate; Triclabendazole; Epothilone B