Vincristine

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Chemical Information

Product name：Vincristine	Purity：98% min
CAS NO：57-22-7	Solubility：Soluble in DMSO
Molecular Formula：C₄₆H₅₆N₄O₁₀	Package：Package according to customer requirements
Molecular Weight：824.958	Storage：Store at -20℃

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Remarks

Vincristine is a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

Microtubule Associated Inhibitors Related Products:

Paclitaxel; Vincristine sulfate; Epothilone A; Fosbretabulin disodium; CW069; CK-636; Docetaxel; Docetaxel trihydrate; ABT-751; Nocodazole; Cabazitaxel; Albendazole; Mertansine; SSE15206; ELR510444; Vinorelbine Tartrate; Triclabendazole; Epothilone B

References

1: Harrison TS, Lyseng-Williamson KA. Vincristine sulfate liposome injection: a guide to its use in refractory or relapsed acute lymphoblastic leukemia. BioDrugs. 2013 Feb;27(1):69-74. doi: 10.1007/s40259-012-0002-5. Review. PubMed PMID: 23329395.

2: Silverman JA, Deitcher SR. MarqiboÂ® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine. Cancer Chemother Pharmacol. 2013 Mar;71(3):555-64. doi: 10.1007/s00280-012-2042-4. Epub 2012 Dec 5. Review. PubMed PMID: 23212117; PubMed Central PMCID: PMC3579462.