Patupilone Epothilone B

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Chemical Information

Product name：Patupilone Epothilone B	Purity：98% min
CAS NO：152044-54-7	Solubility：DMSO: 125 mg/mL (Need ultrasonic)
Molecular Formula：C₂₇H₄₁NO₆S	Package：Package according to customer requirements
Molecular Weight：507.68	Storage：Store at -20℃

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Remarks

Patupilone, also known as Epothilone B and EPO-906, is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Epothilone B may cause complete cell-cycle arrest.

Microtubule Associated Inhibitors Related Products:

Paclitaxel; Vincristine; Vincristine sulfate; Epothilone A; Fosbretabulin disodium; CW069; CK-636; Docetaxel; Docetaxel trihydrate; ABT-751; Nocodazole; Cabazitaxel; Albendazole; Mertansine; SSE15206; ELR510444; Vinorelbine Tartrate; Triclabendazole

References

[1]. Regueiro-Ren A, et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6.

[2]. Pagano A, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43.

[3]. Oehler C, et al. The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol. 2011 Sep;13(9):1000-10.