Cabazitaxel

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Chemical Information

Product name：Cabazitaxel	Purity：98% min
CAS NO：183133-96-2	Solubility：DMSO : ≥ 100 mg/mL (119.63 mM)
Molecular Formula：C₄₅H₅₇NO₁₄	Package：Package according to customer requirements
Molecular Weight：835.932	Storage：Store at -20℃

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Remarks

Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.

Microtubule Associated Inhibitors Related Products:

Paclitaxel; Vincristine; Vincristine sulfate; Epothilone A; Fosbretabulin disodium; CW069; CK-636; Docetaxel; Docetaxel trihydrate; ABT-751; Nocodazole; Albendazole; Mertansine; SSE15206; ELR510444; Vinorelbine Tartrate; Triclabendazole; Epothilone B

References

[1]. Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29.

[2]. Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond). 2017 Sep;12(17):2083-2095.