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BIX02188 1094614-84-2
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Chemical Information
Product name:BIX02188 Purity:98% min
CAS NO:1094614-84-2 Solubility:10 mM in DMSO
Molecular Formula:C20H25NO4 Package:Package according to customer requirements
Molecular Weight:343.417 Storage:Store at -20℃
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BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1,800 nM, respectively). Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

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