APS-2-79 HCl

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Chemical Information

Product name：APS-2-79 HCl	Purity：99% min
CAS NO：2002381-31-7	Solubility：DMSO: 97 mg/mL (228.83 mM)
Molecular Formula：C₂₃H₂₂ClN₃O₃	Package：Package according to customer requirements
Molecular Weight：423.897	Storage：Store at -20℃

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Remarks

APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.

MEK Inhibitor Related Products:

Selumetinib; Mirdametinib (PD0325901); Trametinib; PD184352 (CI-1040); PD98059; BIX02189; U0126-EtOH; Pimasertib; BIX02188; TAK-733; Binimetinib (MEK162); SL327; Refametinib; GDC-0623; RO5126766 (CH5126766); Cobimetinib ; AZD8330

References

[1]. Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Sep 1;537(7618):112-116.