CI-1040 PD184352

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Chemical Information

Product name：CI-1040 PD184352	Purity：98% min
CAS NO：212631-79-3	Solubility：DMSO: ≥ 150 mg/mL
Molecular Formula：C₁₇H₁₄ClF₂IN₂O₂	Package：Package according to customer requirements
Molecular Weight：478.660	Storage：Store at -20℃

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Remarks

CI-1040, also known as PD184352, is a MEK inhibitor, which demonstrated in vivo activity in preclinical animal models and subsequently became the first MEK inhibitor to enter clinical trial. CI-1040 suffered however from poor exposure due to its poor solubility and rapid clearance, and as a result, development of the compound was terminated.

MEK Inhibitor Related Products:

Selumetinib; Mirdametinib (PD0325901); Trametinib; PD98059; BIX02189; U0126-EtOH; Pimasertib; BIX02188; TAK-733; Binimetinib (MEK162); SL327; Refametinib; GDC-0623; RO5126766 (CH5126766); Cobimetinib; APS-2-79 hydrochloride ; AZD8330

References

[1]. Allen LF, et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol. 2003 Oct;30(5 Suppl 16):105-16.

[2]. Wei CR, et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20(10):1961-8.