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Trametinib GSK1120212

Trametinib GSK1120212 871700-17-3
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Chemical Information
Product name:Trametinib GSK1120212 Purity:98% min
CAS NO:871700-17-3 Solubility:10 mM in DMSO
Molecular Formula:C26H23FIN5O4 Package:Package according to customer requirements
Molecular Weight:615.395 Storage:Store at -20℃
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Remarks

Trametinib, also known as GSK1120212, is a n orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. On May 29, 2013, FDA approved T rametinib.

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