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BAY 869766 Refametinib

BAY 869766 Refametinib 923032-37-5
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Chemical Information
Product name:BAY 869766 Refametinib Purity:98% min
CAS NO:923032-37-5 Solubility:DMSO : ≥ 31 mg/mL (54.16 mM)
Molecular Formula:C19H20F3IN2O5S Package:Package according to customer requirements
Molecular Weight:572.337 Storage:Store at -20℃
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Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor RDEA119 specifically inhibits mitogen-activated protein kinase kinase 1 (MAP2K1 or MAPK/ERK kinase 1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.
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