K02288

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Chemical Information

Product name：K02288	Purity：98% min
CAS NO：1431985-92-0	Solubility：DMSO : ≥ 58.6 mg/mL (166.30 mM)
Molecular Formula：C₂₀H₂₀N₂O₄	Package：可按客户要求包装
Molecular Weight：352.38	Storage：-20℃

Quality control

Remarks

K02288 is a potent inhibitor of BMP signaling. K02288 has in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos.

TGF-beta/Smad Inhibitors Related Products:

SB431542; LDN-193189; Galunisertib; LY2109761; SB525334; SB-505124; GW788388; LY364947; RepSox; A-83-01; LDN-212854; PD169316; ITD-1; LY3200882; Dorsomorphin; Dorsomorphin 2HCl; Kartogenin

References

[1]. Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721.

[2]. Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18(2):209-17.