RepSox

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Chemical Information

Product name：RepSox	Purity：98.0% min
CAS NO：446859-33-2	Solubility：DMSO : 33.33 mg/mL (116.00 mM)
Molecular Formula：C₁₇H₁₃N₅	Package：Package according to customer requirements
Molecular Weight：287.32	Storage：Store at -20℃

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Remarks

RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively.

Properties:

Density: 1.297g/cm3

Boiling Point: 501.911ºC at 760 mmHg

Flash Point: 230.461ºC

Refractive Index: 1.692

TGF-beta/Smad Inhibitors Related Products:

SB431542; LDN-193189; Galunisertib; LY2109761; SB525334; SB-505124; GW788388; LY364947; K02288; A-83-01; LDN-212854; PD169316; ITD-1; LY3200882; Dorsomorphin; Dorsomorphin 2HCl ; Kartogenin

References

[1]. Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506.

[2]. Ichida JK, et al. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 6;5(5):491-503.