GW788388

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Chemical Information

Product name：GW788388	Purity：98% min
CAS NO：452342-67-5	Solubility：DMSO : ≥ 48 mg/mL (112.81 mM)
Molecular Formula：C₂₅H₂₃N₅O₂	Package：Package according to customer requirements
Molecular Weight：425.482	Storage：Store at -20℃

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Remarks

GW788388 is a new TGF-beta type I receptor inhibitor with a much improved pharmacokinetic profile compared with SB431542. We studied its effect in vitro and found that it inhibited both the TGF-beta type I and type II receptor kinase activities, but not that of the related bone morphogenic protein type II receptor. Further, it blocked TGF-beta-induced Smad activation and target gene expression, while decreasing epithelial-mesenchymal transitions and fibrogenesis.

TGF-beta/Smad Inhibitors Related Products:

SB431542; LDN-193189; Galunisertib; LY2109761; SB525334; SB-505124; LY364947; RepSox; K02288; A-83-01; LDN-212854; PD169316; ITD-1; LY3200882; Dorsomorphin; Dorsomorphin 2HCl ; Kartogenin

References

[1]. Petersen M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int, 2008, 73(6), 705-715.

[2]. Tan SM, et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol, 2010, 298(5), H1415-1425.