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LY2109761

LY2109761 700874-71-1
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Chemical Information
Product name:LY2109761 Purity:98% min
CAS NO:700874-71-1 Solubility:Soluble in DMSO
Molecular Formula:C26H27N5O2 Package:Package according to customer requirements
Molecular Weight:441.525 Storage:Store at -20℃
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Remarks

LY2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor. The effect of LY2109761 has been evaluated on soft agar growth, migration, invasion using a fibroblast coculture model, and detachment-induced apoptosis (anoikis) by Annexin V flow cytometric analysis. The efficacy of LY2109761 on tumor growth, survival, and reduction of spontaneous metastasis have been evaluated in an orthotopic murine model of metastatic pancreatic cancer expressing both luciferase and green fluorescence proteins (L3.6pl/GLT). In vivo, LY2109761 , in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases.


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