A-83-01

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Chemical Information

Product name：A-83-01	Purity：98% min
CAS NO：909910-43-6	Solubility：DMSO : 30 mg/mL (71.17 mM)
Molecular Formula：C₂₅H₁₉N₅S	Package：Package according to customer requirements
Molecular Weight：421.517	Storage：Store at -20℃

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Remarks

A-83-01 is an ALK inhibibitor. It was found that A-83-01 inhibited the transcriptional activity induced by TGF-beta type I receptor ALK-5 and that by activin type IB receptor ALK-4 and nodal type I receptor ALK-7, the kinase domains of which are structurally highly related to those of ALK-5. A-83-01 was found to be more potent in the inhibition of ALK5 than a previously described ALK-5 inhibitor, SB-431542, and also to prevent phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta. A-83-01 inhibited the epithelial-to-mesenchymal transition induced by TGF-beta, suggesting that A-83-01 and related molecules may be useful for preventing the progression of advanced cancers.

Properties:
Density: 1.27g/cm3
Boiling Point: 590ºC at 760 mmHg
Flash Point: 310.6ºC
Refractive Index: 1.706

TGF-beta/Smad Inhibitors Related Products:

SB431542; LDN-193189; Galunisertib; LY2109761; SB525334; SB-505124; GW788388; LY364947; RepSox; K02288; LDN-212854; PD169316; ITD-1; LY3200882; Dorsomorphin; Dorsomorphin 2HCl ; Kartogenin

References

1: Spinato S, Galindo-Moreno P, Zaffe D, Bernardello F, Soardi CM. Is socket healing conditioned by buccal plate thickness? A clinical and histologic study 4 months after mineralized human bone allografting. Clin Oral Implants Res. 2012 Nov 21. doi: 10.1111/clr.12073. [Epub ahead of print] PubMed PMID: 23167308.

2: Chen WP, Wu SM. Small molecule regulators of postnatal Nkx2.5 cardiomyoblast proliferation and differentiation. J Cell Mol Med. 2012 May;16(5):961-5. doi: 10.1111/j.1582-4934.2011.01513.x. PubMed PMID: 22212626; PubMed Central PMCID: PMC3325363.