PD169316

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Chemical Information

Product name：PD169316	Purity：98% min
CAS NO：152121-53-4	Solubility：DMSO : 12.5 mg/mL (34.69 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₂₀H₁₃FN₄O₂	Package：Package according to customer requirements
Molecular Weight：360.341	Storage：Store at -20℃

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Remarks

PD 169316 is a highly selective, potent inhibitor of p38 MAP kinase. PD 169316 inhibits transforming growth factor β-induced Smad signaling in human ovarian cancer cells. PD 169316 acts as an an endogenous suppressor of apoptosis by mimicking CD9, a membrane tetraspanin. Studies show that PD 169316 reduces myocardial ischemia/reperfusion induced voltage-dependent anion channel(VDAC) phosphorylation.

Properties:
Density: 1.345 g/cm3
Boiling Point: 583.1ºC at 760 mmHg
Flash Point: 306.4ºC

TGF-beta/Smad Inhibitors Related Products:

SB431542; LDN-193189; Galunisertib; LY2109761; SB525334; SB-505124; GW788388; LY364947; RepSox; K02288; A-83-01; LDN-212854; ITD-1; LY3200882; Dorsomorphin; Dorsomorphin 2HCl ; Kartogenin

References

[1]. Fu Y, et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7.

[2]. Hu W, et al. Suppression of Nestin reveals a critical role for p38-EGFR pathway in neural progenitor cell proliferation. Oncotarget. 2016 Dec 27;7(52):87052-87063.