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Carfilzomib (PR-171)

Carfilzomib (PR-171) 868540-17-4
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Chemical Information
Product name:Carfilzomib (PR-171) Purity:98% min
CAS NO:868540-17-4 Solubility:10 mM in DMSO
Molecular Formula:C40H57N5O7 Package:Packaging according to customer requirements
Molecular Weight:719.91 Storage:Store at -20℃
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Carfilzomib, also known as PR-171, is a tetrapeptide epoxyketone and an epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth. Carfilzomib was approved by the FDA for use in patients with relapsed and refractory multiple myeloma on 20 July 2012.
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