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Tyrphostin A9 Malonoben

Tyrphostin A9 Malonoben 10537-47-0
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Chemical Information
Product name:Tyrphostin A9 Malonoben Purity:98% min
CAS NO:10537-47-0 Solubility:DMSO : 50 mg/mL (177.07 mM)
Molecular Formula:C18H22N2O Package:Package according to customer requirements.
Molecular Weight:282.380 Storage:Store at -20℃
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Tyrphostin A9(AG 17), a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. IC50 value: Target: Multi tyrosine kinase Tyrphostin A9 inhibited TNF-induced tyrosine phosphorylation of pyk2 without blocking the cells' bactericidal activity. Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor (IC50 = 500 nM). Recent findings suggest that signaling via PDGF receptor tyrosine kinases is not necessary for the shift of the smooth muscle cells from a contractile to a synthetic phenotype. On the other hand these enzymes apparently carry out important functions in the control of intracellular membrane traffic and cell division.




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