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SAR-131675

SAR-131675 1433953-83-3
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Chemical Information
Product name:SAR-131675 Purity:98% min
CAS NO:1433953-83-3 Solubility:DMSO : ≥ 28 mg/mL (78.13 mM)
Molecular Formula:C18H22N4O4 Package:Package according to customer requirements
Molecular Weight:358.392 Storage:Store at -20℃
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Remarks
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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