ZM 306416

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Chemical Information

Product name：ZM 306416	Purity：98% min
CAS NO：690206-97-4	Solubility：DMSO : 50 mg/mL (149.82 mM)
Molecular Formula：C₁₆H₁₃ClFN₃O₂	Package：Package according to customer requirements
Molecular Weight：333.745	Storage：Store at -20℃

Quality control

Remarks

ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC₅₀=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC₅₀>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC₅₀ value of 1.3±0.2 μM toward the ABL kinase.

Related Prodcuts:

LY2874455; ZM323881; Tyrphostin A9; Orantinib; Brivanib; Foretinib; SU5402; Semaxanib; SAR131675; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932

References

[1]. Han SY, Park SS, Lee WG, Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16(1):129-33.

[2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99.