SU5402

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Chemical Information

Product name：SU5402	Purity：98% min
CAS NO：215543-92-3	Solubility：DMSO : ≥ 30 mg/mL (101.24 mM)
Molecular Formula：C₁₇H₁₆N₂O₃	Package：Package according to customer requirements
Molecular Weight：296.321	Storage：Store at -20℃

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Remarks

SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively).

Chemical Name:

3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

Properties:

Appearance & Physical State:Yellow-Green Solid

Density: 1.363g/cm3

Boiling Point: 592.6ºC at 760 mmHg

Melting Point: >222ºC (dec.)

Flash Point: 312.2ºC

Refractive Index: 1.688

Vapor Pressure: 6.84E-15mmHg at 25°C

Related Prodcuts:

LY2874455; ZM-306416; ZM323881; Tyrphostin A9; Orantinib; Brivanib; Foretinib; Semaxanib; SAR131675; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932

References

[1]. Sun L, et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 1999 Dec 16;42(25):5120-30.

[2]. Kachel P, et al. Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue. BMC Cancer. 2015 Mar 18;15:140.