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E-3810 Lucitanib

E-3810 Lucitanib 1058137-23-7
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Chemical Information
Product name:E-3810 Lucitanib Purity:98% min
CAS NO:1058137-23-7 Solubility:DMSO : ≥ 25 mg/mL (56.37 mM)
Molecular Formula:C26H25N3O4 Package:Package according to customer requirements
Molecular Weight:443.494 Storage:Store at -20℃
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Remarks

Lucitanib , also known as E-3810 and AL3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.

 

 

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